Acute Myeloid Leukemia (AML) and Its Treatment

AML, a form of blood cancer, originates from young white blood cells in the bone marrow. Rapid growth of abnormal cells disrupts normal blood cell production, leading to characteristic symptoms and complications.

Causes and Risk Factors of Acute Myeloid Leukemia

AML is triggered by genetic mutations in bone marrow cells, prompting excessive growth of immature white blood cells. Risk factors include age, gender, previous cancer treatment, radiation exposure, chemical exposure, and smoking.

Signs and Symptoms of Acute Myeloid Leukemia

Symptoms encompass fever, bone pain, fatigue, shortness of breath, pale skin, infections, bruising, and unusual bleeding. Timely diagnosis involves blood tests, bone marrow aspiration, and specific blood tests.

Diagnostic Process 

To diagnose Acute Myeloid Leukemia (AML), several diagnostic tests are typically performed:

1. Complete Blood Count (CBC): This test measures the number of white blood cells, red blood cells, and platelets in the blood. People with AML often have an increased number of white blood cells, insufficient red blood cells, and insufficient platelets
2. Bone Marrow Test: A needle is used to remove a sample of your bone marrow, usually from your hip bone. The sample is then examined in a laboratory to check for leukemia cells.
3. Spinal Tap (Lumbar Puncture): In certain situations, it may be necessary to remove some of the fluid around your spinal cord to check for leukemia cells. Your doctor can collect this fluid by inserting a small needle into the spinal canal in your lower back.
4. Genetic Testing: Doctors test your leukemia cells to understand better which gene mutations are present. This can help determine your prognosis and guide your treatment.
5. Physical Exam and Medical History: The doctor will want to get a thorough medical history, focusing on your symptoms and how long you have had them. They might also ask about other health problems, as well as about possible risk factors for leukemia.

Treatment Options for Acute Myeloid Leukemia

1. Chemotherapy

• Induction Phase chemotherapy: During the Induction Phase of chemotherapy, patients undergo a rigorous and intense treatment aimed at eliminating leukemia cells. This initial stage is characterized by a focused and powerful therapeutic approach to combat the disease at its core.
• Consolidation Phase chemotherapy: Following the successful completion of the Induction Phase, the Consolidation Phase of chemotherapy commences. This involves supplementary treatment designed to further solidify and maintain the achieved remission. The Consolidation Phase is crucial in ensuring a sustained response and reducing the likelihood of leukemia recurrence

2. Bone Marrow Transplant (BMT)

A Bone Marrow Transplant (BMT), also referred to as a stem cell transplant, is a viable treatment option for AML patients, including those in older age groups. In this procedure, the unhealthy blood-forming cells (stem cells) are replaced with healthy ones. These stem cells can be sourced either from the patient’s own bloodstream or obtained from a donor’s blood.

The predominant type of transplant employed for AML is an allogeneic transplant. In this method, stem cells are procured from a healthy, compatible donor, often a close relative such as a sibling. A Stem Cell Transplant (SCT) holds the potential to be a curative option for certain individuals dealing with AML.

Costs of Treatment for Acute Myeloid Leukemia

Costs for Allogenic Bone Marrow Transplant Treatment for Acute Myeloid Leukemia –  The cost for Chemotherapy for AML would be 800$ per cycle, and Allogenic BMT will range somewhere between 24000$ to 28000$ depending upon the choice of hospital and doctor.

Hospital Stay and Follow-ups in India

Following discharge, the patient may need to remain in the hospital for an additional 28 days, with a few extra days dedicated to necessary follow-up appointments.

1. Flight Restrictions: Avoid travel during the initial 100 days post-transplant. Restrict air travel and public transport for 9 to 12 months if possible.
2. Complications and Expectations: Complications include thrombosis, organ spread, and additional symptoms. BMT is a potential cure, with success influenced by various factors.
3. Prognosis and Success Rate: India boasts an annual average of 2,500 BMTs, with a success rate ranging from 60% to 90%, placing it among the leading countries for bone marrow transplants.

How HBG Can Help

HBG Medical Assistance connects you with the top hospitals and doctors for Acute Myeloid Leukemia treatment in India. 

Furthermore, HBG Medical Assistance, a prominent medical travel company in India, extends a comprehensive suite of services to international patients seeking sickle cell treatment. Navigating every aspect of the healthcare journey, HBG offers vital support such as visa assistance, accommodation arrangements, logistics coordination, and the assignment of a dedicated case manager. With a commitment to minimizing waiting times and ensuring cost-effectiveness, the company prioritizes transparency in all financial aspects. Patients benefit from the option to choose from the top hospitals, along with the convenience of translator services. Additionally, HBG facilitates foreign currency exchange, streamlining the overall experience for individuals seeking medical care in India. Understanding AML and its treatment is crucial for informed decision-making. Consultation with healthcare professionals ensures tailored care and optimal outcomes for individuals facing this challenging diagnosis.

Doctors and Hospitals Best for Acute myeloid Leukemia AML Treatment in India