Doctors in Israel have come out with treatment for relapse cases of Blood Cancer. This treatment can be given even after the patient has been administered Bone Marrow Transplant or Chemotherapy and still the cancer has not been treated or has come back.
The fight back therapy for Blood Cancers –
The therapy has come as a boon to those patients who have been treated completely for Multiple Myeloma or ALL (Acute Lymphoblastic Leukaemia) with chemotherapy and Bone Marrow Transplant but the Cancer has come back. For such cases as already chemotherapy and BMT has been administered, there was no hope left. But Now, with CAR-T cell transplant, the lives of such patients who have relapsed case of blood cancer, can be saved. The therapy has been proven wide spread success with 90% of patient showing complete remission. Earlier the therapy was mostly targeted towards children with ALL but now, it is getting delivered even for adults who have gone through failed chemotherapy or failed Bone Marrow Transplant.
How does Chimeric Antigen Receptor T-Cell Therapy Works ?
Our immune system is a powerful biological machine made up of specific cells and organs that protects the body from infection and diseases. An army of T cells petrol throughout the body for signs of infection and other diseases. The T cells inspect the suspicious cells and when they find an abnormal one, immediately lead attack on it while limiting the damage to healthy cells.
T cells have protein receptors or antennae on their surface which are designed to attach themselves to protein fragments found on the surface of all cells called Antigens. Sometimes these antigens can be abnormal, alerting the T cells for action. Whenever T cells discover a cancer cell, it latches onto antigen found on that cancer cell and “Turns On” to release toxic chemicals that destroy that cancer cell.
Sometimes cancer cells develop ways to fool our immune system, specially T cells, and evade its defences by distinguishing themselves as healthy cells or by sprouting many antigens on their surface. As a result, T cells stop recognizing them as foreign and no longer do their job of destroying them. This is how Cancer develops.
Chimeric Antigen Receptor or CAR T –cells treatment is created from a patient’s own T cells , engineered in a lab to be re-infuse in large numbers into patient so as to recognize and destroy cancer cells . CAR-T Cell Therapy is designed to strengthen and harness the immune system’s inherent cancer eliminating powers and remove its disguise. CAR T-Cell therapy is the name given to Chimeric Antigen Receptor or genetically modified T-cells , which is used for the treatment of cancers specially blood cancers. As there are no drugs involved , CAR T-Cell Therapy is also called “ Live Drug”
The processing of “ Live Drug “ starts with collecting thousands of patient own T cells through a process called Leukapheresis. Once T-cells are separated, they are sent to the lab where these cells are genetically modified and reprogrammed so that they can produce a special Chimeric Antigen Receptor. These newly engineered cells are expanded in the lab and millions of them are re-infused back into the patient following a short course of chemotherapy. The new chimeric antigen receptor specially developed in modified T cells enable them to latch onto a specific antigen that is found on the patient cancer cells and destroy them.
Where is the Therapy Available ?
This treatment is currently available in Israel. HBG Medical Assistance has special agreement with Hadasaah Hospital in Jerusalem, Israel to assist patient who are need of CAR-T Cell Therapy. Hadassah University Hospital is one of the leading institutes to offer CAR-T. This exciting new treatment is showing incredible promising results for many patients suffering from blood cancer. Israel with expertise in the CAR T Cell Therapy treatment is redefining cancer treatment.
What is the Cost of the Treatment?
Though, the treatment is costly and the cost of treatment may vary from Rs.1.25 cr to 2.5 cr depending upon case to case ($1,75,000 to $3,50,000), many people from world over are now traveling to Israel to get this treatment done. HBG Medical Assistance has helped a few patients to take this treatment and save lives.
How can one access this Treatment?
Frequently Asked Questions ?
- Where can I take treatment for CAR-T Cell Therapy?
You can take this therapy in Israel. You may like to read more about the institute by clicking here – Hadassah
- I have already gone through a Bone Marrow Transplant, will I need to go through Bone Marrow Transplant again?
No, CAR-T therapy is offered to those patient for whom the Bone Marrow Transplant has not worked. It is a therapy offered to those whose Bone Marrow Transplant has failed or the Chemotherapy has failed.
- I have already gone through Chemotherapy. Will I need to go through the chemotherapy again.
This will largely depend upon how bad the situation is. If the doctors feel that the therapy will work better if we give a few chemo sessions 1st then you will be advised accordingly.
- Who will make the arrangements for my visit to Hadassah Institute?
HBG Medical Assistance, India’s Most Popular Medical Assistance Company will make all the needful arrangements for you.
- How do I Start to get CAR-T Therapy?
You will need to share all you medical reports (at least the latest ones) with us at [email protected] along with the passport scans of patient and care giver. We will discuss the reports of patient with Doctor’s at Israel Hospitals. On the basis of the reports, the doctors in Israel will evaluate if the therapy can be delivered and will give a final cost.
- Will there be any charge for the opinion and quotation?
No the opinion and the quotation will come at free of cost.
- Will my reports be confidential ?
Your reports will be shared with relevant doctors and hospitals.
- What are the service charges of HBG Medical Assistance?
HBG will not have any service charges for there services. You will only need to pay to the hospital.
Other Related Information on CAR-T Cell Therapy, Blood Cancers, Israel
Bone Marrow Transplants – Bone Marrow Transplants in India
Best Cancer Hospital – Best Cancer Hospital in India
Hospitals in Israel – Hadassah Hospital in Israel
Other Treatments in Israel – Recently Developed Cancer Treatment in Israel
News Articles Related to CAR-T Cell Therapy –
Science Daily – June 25, 2021 – Potential New Car-T cell therapy for multiple myeloma
EurekAlert ! – June 25, 2021 – Mayo Clinic researchers study potential new CAR-T cell therapy for multiple myeloma
AJMC – June 8, 2021 – Advances, Outcomes in CAR T-Cell Therapies and Management Challenges