An Autologous Bone Marrow Transplant (ABMT), also known as an Autologous Stem Cell Transplant or Bone Marrow Transplant is an advanced medical procedure in which a patient’s own healthy blood-forming stem cells are collected, preserved, and later reinfused after the patient receives high-dose chemotherapy. The treatment is designed to rescue and restore healthy bone marrow function after intensive therapy aimed at eliminating cancer cells.
This procedure is a cornerstone in the treatment of various hematological (blood) cancers and oncological conditions, offering patients a path toward deep disease control, prolonged remission, and long-term recovery.
An Autologous Bone Marrow Transplant is most frequently recommended for patients diagnosed with:
Multiple Myeloma
Hodgkin Lymphoma
Non-Hodgkin Lymphoma
Certain types of Leukemia (such as Acute Myeloid Leukemia)
Neuroblastoma (primarily in pediatric cases)
Selected autoimmune or blood disorders
The primary goal of an Autologous Bone Marrow Transplant is to allow patients to tolerate much higher, more effective doses of chemotherapy than their bone marrow could normally survive. While high-dose chemotherapy destroys the cancer, it also destroys the blood-making cells in the bone marrow; reinfusing the saved stem cells acts as a safety net to rebuild the system.
1. Pre-Transplant Assessment
The patient undergoes rigorous medical testing—including extensive blood work, imaging (PET/CT scans), bone marrow biopsies, and cardiac/lung function tests—to ensure their organs are strong enough to safely tolerate the intensive treatment.
2. Stem Cell Mobilization and Collection
Patients receive injections of growth factors (and sometimes low-dose chemotherapy) to stimulate the bone marrow to produce an abundance of stem cells and push them into the bloodstream. These cells are then collected via a machine through a process called apheresis (similar to a specialized blood donation) and are safely cryopreserved (frozen) until needed.
3. High-Dose Conditioning Chemotherapy
The patient is admitted to the hospital or specialized transplant unit to receive intensive, high-dose chemotherapy. This phase targets any remaining cancer cells in the body, but temporarily wipes out the patient’s existing bone marrow and immune system.
4. Stem Cell Reinfusion (The “Transplant”)
A day or two after the chemotherapy conditioning ends, the frozen stem cells are thawed and reinfused back into the patient through a central venous catheter, a painless process very similar to a standard blood transfusion.
5. Engraftment and Recovery
Over the next 2 to 3 weeks, the infused stem cells travel through the bloodstream to the bone marrow cavities, nestle in, and begin producing new blood cells. This critical milestone is called engraftment. During this phase, patients are kept in a highly protective, clean environment and given supportive care (blood transfusions, antibiotics, and nutritional support) until their immune systems recover.
No Risk of Rejection or GVHD: Because the procedure uses the patient’s own cells, the immune system will not reject them. Furthermore, there is zero risk of Graft-versus-Host Disease (GVHD), which is a serious, tissue-attacking complication common in donor (allogeneic) transplants.
Enables Intensive Therapy: It allows for aggressive, potentially curative doses of chemotherapy that otherwise couldn’t be safely administered due to bone marrow toxicity.
Established Success: It is a well-standardized, highly effective, and widely utilized treatment protocol globally with a predictable recovery timeline.
Temporary Immune Suppression: Patients will have severely low white blood cell counts for a few weeks after chemo, creating a high risk for infections that require strict protective isolation and hygiene protocols.
Temporary Side Effects: High-dose chemotherapy causes temporary side effects including severe fatigue, nausea, hair loss, loss of appetite, and painful mouth sores (mucositis).
Specialized Infrastructure Required: The procedure must be performed at a dedicated transplant center with specialized medical infrastructure and expert nursing care.
Variable Recovery Time: While initial blood count recovery (engraftment) takes a few weeks, full energy levels and complete immune system maturity can take several months to a year to return to normal.
Looking for the cost of autologous bone marrow transplant (BMT) in India? Discover affordable options for autologous stem cell transplant for multiple myeloma and trusted treatment for bone marrow transplant for leukemia in India. Get affordable cost estimates for Autologous BMT surgery in India in leading Indian cities such as Ahmedabad, Delhi (NCR), Bangalore, Chennai, Gurgaon, Mumbai, Hyderabad, and Faridabad.
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HCG Hospital – Dr. Abhishek Dudhatra – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 18000 – 20000
KD Hospital – Dr. Abhishek Kakroo – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
BLK-Max Hospital – Dr. Dharma Choudhary – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 18000 – 20000
Apollw Hospital – Dr. Shishir Seth – Cost of Investigation USD 500-800 and Cost of Treatment USD 18000 – 20000
Manipal Hospital – Dr. Peush Bajpai – Cost of Investigation USD 500-800 and Cost of Treatment USD 18000 – 20000
Gleneagles Global Hospital – Dr. Rajiv – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 14000 – 16000
HCG Hospital – Dr. Nataraj K S – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 18000 – 20000
Manipal Hospital – Dr. Ashish Dixit – Cost of Investigation USD 500-800 and Cost of Treatment USD 18000 – 20000
Gleneagles Global Hospital – Dr. S Rajasundaram – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
Artemis Hospital – Dr. Gaurav Dixit – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 16000 – 18000
Fortis Healthcare Hospital – Dr. Rahul Bhargava – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 18000 – 20000
Sanar International Hospital – Dr. Satyendra Katewa – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 15000 – 17000
Medanta Hospital – Dr. Nitin Sood – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 18000 – 20000
Marengo Asia Hospital – Dr. Meet Kumar – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
Nanavati Max Hospital – Dr. Balkrishna Padate – Cost of Investigation USD 500-800 and Cost of Treatment USD 18000 – 20000
Gleneagles Global Hospital – Dr Ravi Kumar – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
Care Hospital – Dr. Sudha Sinha – Cost of Investigation USD 500-800 and Cost of Treatment USD 18000 – 20000
KIIMS Hospital – Dr. Narender Kumar Thota – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
Amrita Hospital – Dr. Pravas Mishra – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 14000 – 16000
Sarvodaya Hospital – Dr. Dinesh Pendharkar – Cost of Investigation USD 1500-2000 and Cost of Treatment USD 15000 – 17000
Marengo Asia Hospital – Dr. Meet Kumar – Cost of Investigation USD 500-800 and Cost of Treatment USD 15000 – 17000
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